Should I be optimizing CSS for a specific browser and screen resolution?

makkai

New Member
I am new to the world coding as well as CSS and would like to know if I should optimize CSS to a specific browser. Also should I be concerned about screen resolution? If so what screen sizes should I be targetting especially if I have very little information about the end-users e.g. will they using laptops with smaller screen resolutions in comparison to desktop, will they be using netbooks, etc
 
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