How to launch an application from a link in a webpage on mac

[F.Y.N.]

I am trying to have an application open when a link is clicked on in a webpage. Lets say if I clicked the link that says iTunes it would open iTunes. I am not sure if this is similar but if you go to an album link for iTunes that opens in the web browser, it will open iTunes to that page. Remember this is for mac. Also, the other tutorials that I have tried did not work. Other tutorials used JavaScript so I am guessing that I will need to use this as well.